myocardial energy storage
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Mechanisms and Drug Intervention for Doxorubicin-Induced …
2. Myocardial Mitochondrial Substrate Metabolism. In normal myocardium, approximately 60%~90% of energy comes from mitochondrial fatty acid β-oxidation, with a limited amount coming from glucose metabolism [].The oxidation of fatty acids is similar to glucose oxidation: both undergo a series of oxidative decarboxylation …
يتعلم أكثرMyocardial Energy Metabolism in Non-ischemic Cardiomyopathy
The feasibility of myocardial energetics optimization as an approach to treat the cardiac pathology associated with these various non-ischemic cardiomyopathies as well as the rare genetic disease, Barth Syndrome is discussed. As the most metabolically demanding organ in the body, the heart must generate massive amounts of energy …
يتعلم أكثرAbnormalities of glucose and lipid metabolism in myocardial …
During myocardial ischemia, there is an increase in fatty acid uptake and metabolism to maintain the balance of myocardial energy requirements and metabolic pathways. However, during reperfusion, this increased fatty acid metabolism can result in oxidative stress and cell death, thereby exacerbating myocardial ischemia-reperfusion …
يتعلم أكثرLactate and Myocardiac Energy Metabolism
Herein, we discuss myocardial energy metabolism, with an emphasis on the role of lactate metabolism and its relevance to the progression and management of …
يتعلم أكثرThe role of mitochondria in myocardial damage caused by energy …
Specifically, mitochondria are the centers of energy metabolism, and recent evidence has shown that decreased mitochondrial function, caused by an …
يتعلم أكثرEnergy metabolism: A critical target of cardiovascular injury
3. Pathological alterations in cardiac energy metabolism3.1. IHD and energy metabolism. IHD is a cardiac syndrome [65] induced by coronary artery diseases and hypoxia induced by coronary artery diseases. During myocardial ischemia, insufficient blood perfusion leads to myocardial hypoxia, general mitochondrial OXPHOS and …
يتعلم أكثرTriptolide improves systolic function and myocardial energy …
Secondarily, we sought to evaluate if Triptolide could improve myocardial energy metabolism. ... in which ATP is a direct energy supplier whereas pCr is energy storage [22, 24, 25]. When muscle contracts, pCr transmits high energy phosphate bond to ATP for energy supply, ...
يتعلم أكثرEnergy metabolism homeostasis in cardiovascular diseases
Mitochondrial biosynthesis, providing enough energy for cellular metabolism, can intensify cellular tolerance to harmful stimuli and maintain myocardial …
يتعلم أكثرThe role of cardiac energy metabolism in cardiac hypertrophy and …
Cardiac muscle adaptations to increased energy demand or compromised energy supply involve coordinated remodelling of the expression of networks of the …
يتعلم أكثرCardiac energy metabolism disorder mediated by energy …
One of the main regulators of myocardial cell metabolism and cellular energy is insulin (Qi et al., 2013). Insulin not only promotes glucose uptake and energy storage, but also controls cardiac energy metabolism, thereby supporting cardiac growth and function (Guo and Guo, 2017).
يتعلم أكثرEffects of Lipid Overload on Heart in Metabolic Diseases
In conclusion, the selection, utilization, and storage of myocardial fuel is a complex physiological process. Cardiac energy metabolism mainly includes three parts: substrate utilization, oxidative phosphorylation, and high-energy phosphate metabolism 21.
يتعلم أكثرMyocardial triacylglycerol metabolism
Myocardial triacylglycerol (TAG) constitutes a highly dynamic fatty acid (FA) storage pool that can be used for an energy reserve in the cardiomyocyte. However, derangements in myocardial TAG metabolism and accumulation are commonly associated with cardiac disease, suggesting an important role of intramyocardial TAG turnover in the regulation …
يتعلم أكثرMyocardial Energy Metabolism in Non-ischemic Cardiomyopathy …
We herein will provide an overview of myocardial energy metabolism in the healthy heart, while describing the numerous perturbations that take place in various …
يتعلم أكثرEffects of Short-Term High-Fat, High-Energy Diet on Hepatic and Myocardial …
Abstract Context: An association has been suggested between elevated plasma nonesterified fatty acid (NEFA) levels, myocardial triglyceride (TG) accumulation, and myocardial function. Objective: Our objective was to investigate the effects of an elevation of plasma NEFA by a high-fat, high-energy (HFHE) diet on hepatic and …
يتعلم أكثرCardiac Metabolism and its Interactions With …
Because the high-energy phosphate storage within the cardiomyocyte is minimal, only sufficient to sustain the heart beat for a …
يتعلم أكثرDegradation of myocardial high-energy phosphates during twenty-four hours of cold storage …
In baboons, energy charge in the cardioplegic arrest group tends to be higher than that of the hypothermic arrest group after 8 hours of preservation, like ATP level, Volume 103 Number 5 May 1992 Effect of cold storage …
يتعلم أكثرA Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage …
These findings suggest hepatic PPP1R3B serves as a metabolic switch favoring hepatic energy storage as glycogen instead of TG. ... A similar trend relating to non-fatal myocardial infarction was ...
يتعلم أكثرControl of Myocardial Fatty Acid Uptake | SpringerLink
The importance of long-chain fatty acids (hereafter referred to as ''fatty acids'') for myocardial homeostasis is well recognized. Apart from their role as a fuel for myocardial energy production, fatty acids are incorporated into phospholipids forming the core of biological membranes and serve in selected signal transduction pathways to alter …
يتعلم أكثرMyocardial triacylglycerol metabolism
Myocardial triacylglycerol (TAG) constitutes a highly dynamic fatty acid (FA) storage pool that can be used for an energy reserve in the cardiomyocyte. However, derangements in myocardial TAG metabolism and accumulation are commonly associated with cardiac disease, suggesting an important role of intramyocardial TAG turnover in the regulation ...
يتعلم أكثرEnergy metabolism homeostasis in cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the general population. Energy metabolism disturbance is one of the early abnormalities in CVDs, such as coronary heart disease, diabetic cardiomyopathy, and heart failure. To explore the role of myocardial energy homeostasis disturbance in CVDs, it is …
يتعلم أكثرDoxorubicin toxicity changes myocardial energy metabolism in rats
Myocardial energy metabolism relates to mitochondrial respiratory chain, oxidative phosphorylation, myocardial substrate utilization, high-energy phosphate storage and transfer and energy signal pathway [12], [13]. Heart consumes large amounts of adenosine triphosphate (ATP) to sustain cardiac systolic function. Hence, energy …
يتعلم أكثرEnergy metabolism homeostasis in cardiovascular diseases
Energy metabolism disturbance is one of the early abnormalities in CVDs, such as coronary heart disease, diabetic cardiomyopathy, and heart failure. To explore the role of myocardial energy homeostasis disturbance in CVDs, it is important to understand myocardial metabolism in the normal heart and their function in the complex …
يتعلم أكثرEvolving Concepts of Myocardial Energy Metabolism
overall myocardial ATP production with negligible actions on myocardial carbohydrate and fatty acid oxidation, this leads to the important question of how altering energy …
يتعلم أكثرPerturbations in myocardial energy metabolism in ischemic …
in the heart, though these storage forms are minimal in . 19. ... a major change in myocardial energy metabolism in diabetic patients is a reduction in glucose oxidation, which negatively ...
يتعلم أكثرProtective mechanism of shenmai on myocardial ischemia-reperfusion through the energy …
Many studies have shown that myocardial energy deficiency, overexpression of metabolic enzymes and gene abnormalities can alter myocardial function and highly affect recovery. A previous study demonstrated that trimetazidine (TMZ) treatment significantly stimulates the cardiac AMP-activated protein kinase (AMPK) and …
يتعلم أكثرFrontiers | Lactate and Myocardiac Energy Metabolism
5 Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, SA, Australia. The myocardium is capable of utilizing different energy substrates, which is referred to as "metabolic flexibility.". This process assures ATP production from fatty acids, glucose, lactate, amino acids, and ketones, in the face of varying metabolic contexts.
يتعلم أكثرMyocardial Energy Metabolism in Non-ischemic Cardiomyopathy
Energy Metabolism in Diabetic Cardiomyopathy. First described in diabetic patients with heart failure in the absence of myocardial ischemia, diabetic cardiomyopathy is characterized by ventricular dysfunction in the absence of underlying coronary artery disease and/or hypertension ( Rubler et al., 1972 ).
يتعلم أكثرEnergy metabolism: A critical target of cardiovascular injury
Altered energy metabolism in ischemic heart diseases and under reperfusion injury. During myocardial ischemia, fatty acid oxidation, ketone body …
يتعلم أكثرMyocardium Metabolism in Physiological and Pathophysiological States: Implications of Epicardial …
The excess energy substrate can be associated with the myocardial dysfunction or high energy substrates intake. However, the high fat accumulation intensifies the proinflammatory activity on this tissue with high production of tumor necrosis factor (TNF-α), interleukin 1β, or IL-6 [ 133 ].
يتعلم أكثرMyocardial energy metabolism in preserved heart: comparison of …
Isolated canine hearts were preserved for 24 hours by either simple hypothermic storage in Collins'' M solution (group 1, n = 7) or hypothermic perfusion with oxygenated modified Krebs solution (group 2, n = 7), followed in both cases by reperfusion with cross circulation. Myocardial biopsies taken c …
يتعلم أكثرAltered Cardiac Energetics and Mitochondrial Dysfunction in ...
Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations most commonly enhance force production, leading to higher energy demands. Despite significant advances in …
يتعلم أكثرHigh-Energy Phosphates and Ischemic Heart Disease: From Bench …
Introduction. The heart is more than a hemodynamic pump. It is also an organ that needs energy from metabolism () fact, altered cardiac metabolism is the primary and upstream pathophysiologic manifestation of myocardial ischemia in humans ().After coronary blood flow blockage, energy metabolism disorder occurs within a few …
يتعلم أكثرEnergy substrate metabolism, myocardial ischemia, and targets …
At the same time, the large amount of Ca 2+ released from the sarcoplasmic reticulum must be pumped back into the storage compartment, an ATP-requiring process. In the end, ... Ischemia affects myocardial energy metabolism by slowing aerobic metabolism and by accelerating anaerobic metabolism. Just as there is a continuum of the relative ...
يتعلم أكثرEvolving Concepts of Myocardial Energy Metabolism
Although mitochondrial fatty acid and carbohydrate oxidation are the major source of ATP production in the heart, it is …
يتعلم أكثرMyocardium Metabolism in Physiological and Pathophysiological …
Thus, after myocardial infarction in rat, there is a high glucose-6-phosphate dehydrogenase activity . If the ischemia is moderate, fatty acid oxidation rate is normal. Even, the high catecholaminergic activity increases fatty acids during myocardial infarction, and they are used as an energy substrate with the residual oxygen . The …
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